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How to Promote Brain Health:
The Healthy Aging Checklist, Part 1

by Leslie Kernisan, MD MPH 17 Comments

Aging brain“Doctor, what do you recommend for healthy aging?”

“My mom is getting older and I want to help her stay healthy. What should we be doing?”

On this blog, I usually write about how to manage or avoid specific senior health challenges. But in real life, I often get asked the questions above. After all, many people want advice on how to be healthier, or stay healthy.

That’s because we all intuitively know that maintaining good health is key to maintaining what is most important to us as we age: our ability to be physically and mentally capable, so that we can remain active, engaged in our lives, and as independent as possible.

We also know that poor health can bring on pain and other symptoms, as well as disabilities that can jeopardize how we live our usual lives. In fact, most “aging” problems that seniors and families struggle with — like difficulties with mobility, memory, or independence —  track back to underlying health problems.

So it’s good to know how to maintain one’s health as one ages, in order to keep our minds and bodies working well for as long as possible.

Furthermore, healthy aging isn’t just about forestalling aging or disability. It’s also about knowing how to make the best of things even once you do have chronic diseases or chronic disabilities of the mind or body. I call this optimizing health, for better health while aging.

It means optimizing one’s health — and health care — so that the brain and body work at their best for now and for the future. And the beauty of this is that the same key things work, whether you are a “healthy” older person with no particular health problems versus someone who has chronic conditions or even an “uncurable” disabling disease such as Alzheimer’s.

In this series of posts, I’m going to tell you how to do this.

The Healthy Aging Checklist

For the healthiest aging, do this:

  • Promote brain health and emotional well-being.
  • Promote physical health.
  • Check for and address common aging health problems (e.g. falls, pain, memory problems, depression, isolation, incontinence, polypharmacy, etc).
  • Learn to optimize the management of any chronic conditions.
  • Get recommended preventive health services for older adults.
  • Address medical, legal, and financial advance care planning.

There you have it. If you do those six things for your older relative — or for yourself — you’ll have set up an excellent foundation for optimizing health right now, preventing or delaying health problems, and being prepared to better navigate the future emergencies and health declines that will probably crop up.

You may be wondering just how to implement each item.  So, I’m creating a cheatsheet for each part, and I’ll cover each of them in a blog post.

Like everything I suggest, it’s based on the approach I take with patients when I practice, and it’s grounded in the geriatrics approach to healthcare for older adults, as well as in clinical research.

In this post, we will cover what to do to promote brain health, and also emotional well-being, which is intimately related to brain health and brain function.

Let’s get to it!

How To Promote Brain Health: 8 Key Things To Do

For better brain health while aging, I recommend you prioritize these eight approaches. There are three unhealthy things to avoid — or at least minimize — and five healthy things to do.

Note that although it’s ideal to do these before a person develops memory problems, these do also promote better brain function in people diagnosed with Alzheimer’s or another dementia.

Get Your Free Brain Health Cheatsheet! The 8 actions to maintain brain health in a handy PDF checklist that you can print or save. Includes useful resources for each action item. Click here.

1. Avoid brain-slowing medications. 

Why: Several types of commonly-used medications diminish brain function in the short-term, and are linked to higher rates of Alzheimer’s in the longer-term. Learn to identify these medications, so that you can avoid them, or at least use them only as a last resort when the likely benefits outweigh the risks.

Note: Common health problems often treated with risky medications include anxiety, insomnia, over-active bladder, vertigo, and allergies. (See resources below for more.) In many cases, such problems can effectively be treated with non-drug approaches, or with safer medications.

For more information:

  • 4 Types of Brain-Slowing Medication to Avoid if You’re Worried About Memory
  • 7 Common Drugs That Are Toxic For Your Brain
  • How You Can Help Someone Stop Ativan

2. Avoid chronic sleep-deprivation.

Why: Chronic sleep-deprivation can cause irritable mood, worse thinking, and many other problems. Fortunately, most sleep problems can be treated if properly identified.

Note: If you have anxiety or frequent insomnia, it’s very important to learn to sleep without sedatives or sleeping pills. This usually requires a big effort in the short-term, but is worthwhile for long-term brain health and will reduce fall risk as well. Clinical studies have shown that older adults who depend on tranquilizers can successfully wean off of them. (See resources below for links to these studies.)

For More Information:

  • How Sleep Affects Health, & Changes with Aging
  • 5 Top Causes of Sleep Problems in Seniors, & Proven Ways to Treat Insomnia

3. Avoid delirium.

Why: Delirium is a state of worse-than-usual mental function, brought on by some kind of illness or stress. Studies have found that delirium is associated with acceleration of cognitive decline. In older adults, delirium is often brought on by the stress of hospitalization or serious illness. Although not all delirium can be avoided or prevented, seniors and families should be careful about elective surgeries, and can learn ways to reduce the chance of developing delirium.

For more information:

  • 10 Things to Know About Delirium
  • Hospital Delirium: What to Know & Do

4. Pursue positive social activities, purposeful activities, and whatever activities nourish the soul.

Why: Loneliness and boredom are harmful to brain health and emotional health. Studies find that older adults feel better when they are socially engaged, and also when they feel a sense of purpose. This may also help prevent or delay cognitive decline.

For more information:

  • The Brain Fights Back: New Approaches to Mitigating Cognitive Decline
  • Higher purpose in life tied to better brain health
  • Social relationships and risk of dementia

5. Find constructive ways to manage chronic stress. 

Why: Chronic stress is an important quality of life issue. It also can change the brain, and has been linked to changes in cognitive function.

Note: To manage chronic stress, it’s best to combine general approaches (such as improving sleep, exercising, meditation, relaxation strategies, etc) with approaches that can help you cope with your specific source of stress, such as caregiving coping skills or relationship counseling.

For more information:

  • Perceived Stress and Change in Cognitive Function Among Adults Aged 65 and Older
  • Chronic Stress Can Damage Brain Structure and Connectivity
  • Mindfulness-Based Stress Reduction for Family Caregivers: A Randomized Controlled Trial
  • Stress Management: How to Reduce, Prevent, and Cope with Stress

6. Seek treatment if any signs of depression or chronic anxiety.

Why: Although studies find that many people feel happier as they age, it’s still quite common for seniors to experience late-life depression. Chronic anxiety is also common, and can co-exist with depression. These problems dimish quality of life, and also have been linked to cognitive decline. Fortunately, they are treatable.

Note: It’s most common for these problems to be treated with medication. However, a number of non-drug treatments are available for depression and anxiety, such as cognitive-behavioral therapy, and these can be as effective as medication. These are often safer for older adults in that there’s less risk of side-effects or interactions with any treatment for other health problems, so it’s often worthwhile to ask about non-drug treatments.

For more information:

  • Depression in Older Adults and the Elderly
  • Anxiety Disorders, Risk Factors and Diagnosis
  • Does Depression Contribute to Dementia?

7. Stay physically active and exercise regularly.

Why: Regular physical activity has been shown to benefit brain health as well as mood. Studies have found that exercise can help treat depression or anxiety, and is also linked to a lower risk of developing a dementia such as Alzheimer’s.

Note: The CDC resource below clarifies how much exercise to get. But research has also shown that even less-than-recommended exercise brings health benefits. So remember: it’s better to do a little bit every day than nothing at all!

For more information:

  • CDC.gov: How much physical activity do older adults need?
  • National Institute on Aging Go4Life.gov: Try These Exercises

8. Address risk factors for cardiovascular disease.

Why: Cardiovascular disease includes cerebrovascular disease, which means brain health problems related to blood vessels in the brain. Reducing cardiovascular risk factors helps preserve good blood flow to the brain. This reduces the risk of a major stroke, and may help prevent the smaller brain vessel blockages that cause vascular dementia.

The main cardiovascular risk factors to address are high blood pressure, high cholesterol, diabetes and pre-diabetes, smoking, obesity, and physical inactivity. Exercise is a safe and effective way to help treat most of these risk factors, but medications or other approaches may also be necessary.

Note: There has been some debate as to how intensively to treat some of these risk factors, e.g. what is ideal blood pressure for older adults, or when to treat high cholesterol with statins.  It’s important to balance the likely benefits of intensive treatment with the likely risks. You can do this by asking about a treatment’s “number-needed-to-treat” (NNT) and “number needed to harm” (NNH); the New York Times articles linked to below explain this further.

For more information:

  • 10-year Cardiovascular Disease Risk Calculator
  • Cerebrovascular disease: Risks and prevention
  • 6 Steps to Better High Blood Pressure Treatment for Older Adults
  • Can This Treatment Help Me? (NYTimes on NNT)
  • How to Measure a Medical Treatment’s Potential for Harm (NYTimes on NNH)

2 Optional Extra Ways to Promote Brain Health

Here are two additional approaches you can try, as part of promoting brain health for healthier aging. Both of these approaches are covered in the Institute of Medicine’s (IOM’s) groundbreaking and very comprehensive 2015 report on cognitive aging, and for both of these approaches, the IOM concluded that the research results are promising but not yet conclusive.

9. Eat based on the Mediterranean Diet.

Why: Several studies over the past few years have indicated that a “Mediterranean diet” is associated with many positive health outcomes. In a large well-done randomized trial, a Mediterranean diet reduced cardiovascular disease in older adults, and was also linked to maintaining better cognitive function.

Note: The medical literature on dietary vitamins and supplements for cognitive health is mixed. I personally believe it’s more useful to focus on maintaining a diet that is generally healthy for the body, such as the Mediterranean diet, than it is to focus on taking specific foods or vitamins for brain health.

For more information:

  • How to Follow the Mediterranean Diet for Senior Health, & Related Research Findings
  • Summary on Dietary Interventions in Cognitive Aging (IOM Report page 126)

10. Consider brain training games if you enjoy doing them.

Why: Mentally challenging activities have been linked to brain health, and studies have found that older adults can improve certain cognitive abilities through brain-training programs. However, brain-training seems to mainly improve one’s ability to do the brain task that is being practiced, and the overall value of the cognitive improvements has been debated.  Hence, the IOM concluded that brain training is promising but in the absence of more research, one should be cautious about the claims being made by those selling cognitive training programs.

Note: I cannot endorse any specific programs, but will say that BrainHQ and Lumosity are particularly well-established companies who often collaborate with clinical researchers. You can read about research studies related to these programs here and here.

For more information:

  • Do Brain Workouts Work? Science Isn’t Sure
  • Cognitive training shows staying power (refers to ACTIVE study which used BrainHQ exercises)
  • Summary on Cognitive Stimulation and Training in Cognitive Aging (IOM Report, page 190)

For More In-Depth Information on Cognitive Aging and Promoting Brain Health

If you want to go beyond the information presented in my brain health cheatsheet, an excellent resource is the aforementioned Institute of Medicine (IOM) report on Cognitive Aging.

This report was published in 2015 and is freely available online. The full report is 318 pages, and covers just about all the relevant scientific knowledge and research on brain health and how to preserve it.

You can find a report brief, additional resources including an action guide for individuals and families, and a link to the full online report here: Cognitive Aging: Progress in Understanding and Opportunities for Action.

You can also read my article summarizing what I found most important in the report here.

How Are You Doing on Promoting Brain Health & What Will You Do Next?

Don’t panic if you realize you aren’t doing most of the eight things I recommend.

Do, however, give yourself credit for any items you are doing well on. And then make a plan to improve just one thing, and pick one little next step. It might be committing to walk 20 minutes every day. Or scheduling an appointment with the pharmacist to review medications.

Whatever it is, pick one thing and schedule it. And then commit to reviewing the cheatsheet and taking one more action next month.

If you take an action at least once a month, you’ll eventually be on track for maintaining better brain health while aging.

Get Your Free Brain Health Cheatsheet! The 8 actions to maintain brain health in a handy PDF checklist that you can print or save. Includes useful resources for each action item. Click here.
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Filed Under: Aging health, Geriatrics For Caregivers Blog, Helping Older Parents Articles Tagged With: brain health, healthy aging, memory

« New Year, New Name:
Introducing Better Health While Aging
How to Promote Physical Health While Aging:
The Healthy Aging Checklist Part 2 »

Comments

  1. Blaikie Worth says

    January 12, 2016 at 7:59 AM

    Excellent and much needed, especially the section on drugs.

    Reply
  2. Gerry Carleton says

    June 6, 2017 at 3:44 PM

    I have a question….recently read a statement from a medical doctor who, when asked what he did to age healthily, responded that he took Vitamim K2. He said it helped direct calcium most seniors took to the proper place, the bones. He believed calcium can enter the arteries and even the heart when taken in too great a quantity. Is this a possibility, and is it worth looking into.?

    Thank you.

    P

    Reply
    • Leslie Kernisan, MD MPH says

      June 7, 2017 at 6:51 AM

      Calcification of coronary arteries and other blood vessels is a known phenomenon, and is associated with cardiovascular disease. How to prevent vessels from calcifying, and whether this actually leads to a reduced risk of cardiovascular events, is still under investigation.

      Vitamin K2 does appear to influence calcium metabolism, so the effect of supplementation is being studied. But it seems to me that all the research is in preliminary stages, and it’s a little too soon to know what to recommend to the general public. Here are two scholarly articles related to vitamin K2:
      Something more to say about calcium homeostasis: the role of vitamin K2 in vascular calcification and osteoporosis
      Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial)

      I think what this other doctor is doing sounds biologically plausible. But plenty of biologically plausible ideas have not panned out once they were more rigorously studied.

      Reply
  3. Deb says

    January 22, 2018 at 1:12 PM

    I’m really scared. My doctor prescribed Xanax and klonapin when my mother passed in 2010 for sleep and anxiety. Was on Xanax for three yrs and now klonapin last two and a half yrs. I was able to wean off Xanax for a yr but had panic attack and another doctor prescribed klonapin. Now I’m ready obsessing about what I’ve read concerning these drugs and Alzheimer’s. As I said. I’m scared!!!! Is this really true?

    Reply
    • Leslie Kernisan, MD MPH says

      January 25, 2018 at 3:56 PM

      Research does suggest that benzodiazepines such as alprazolam (Xanax) and clonazepam (Klonopin) are associated with a higher risk of developing dementia, but not all experts agree with that conclusion.

      What is more clear, in terms of research and clinical experience, is that benzodiazepines do somewhat impair thinking abilities in the short-term, and also interfere with balance in the short-term. So if an older person eventually does develop a disorder such as Alzheimer’s — and most people who live into their 70s or 80s have a 30-50% chance of eventually developing some form of dementia — then being on a benzodiazepine will keep their thinking from being the best it can be, and will further increase fall risk. (Dementia in of itself increases fall risk.)

      The thing about benzodiazepines, as you’ve probably already noticed, is that they are habit-forming. They can’t quickly be stopped, but they CAN be successfully tapered down with time and effort, ESPECIALLY if a person also gets coached on how to manage sleep and anxiety without medication. Cognitive-behavioral therapy is especially helpful for these two conditions and has a good track record.

      If you’re concerned about your use of these medications, I would encourage you to print the educational brochure available in this article, and then discuss it with your health providers: How You Can Help Someone Stop Ativan.

      Be sure to ask for help accessing other ways to manage anxiety. Cognitive-behavioral therapy can be combined with mindfulness exercises, relaxation therapies, and many other approaches that help make anxiety more manageable. Learning to manage stress and worry without medications is one of the best investments in oneself that one can make. Good luck!

      Reply
  4. Venkatesan says

    August 27, 2018 at 5:22 AM

    Excellent Mam. I have been following your tips ever since I have been affected by CSVD & atrophy. Im taking medicines for nerve damage but for brain shrinkage & csvd no direct tablets have been prescribed. But the probelms goes on. Apart from the above problems insomnia also joins. As all the tablets r having side effects presently Im taking Coenzyme tablets. Primarily it was effective but now it has lost its effect. In my experience my opinion no cure for brain diseases & v have to struggle with all these. No permanent cure. But the above tips r very usefl. Thank U.

    Reply
    • Leslie Kernisan, MD MPH says

      August 27, 2018 at 5:16 PM

      Glad you found the article helpful. Sorry if your problems are persisting. Some forms of brain difficulty are indeed difficult to permanently cure. However the strategies in this article generally help the brain work at its best, whether or not a person has a brain condition. Good luck!

      Reply
  5. susan says

    January 12, 2019 at 9:41 AM

    I have been told I should not continue taking hormones….estradial and progestren. I still get hot flashes although not as extreme as they use to be. I am 75 and in good health. What do you think…just speaking generically?

    Reply
    • Leslie Kernisan, MD MPH says

      January 15, 2019 at 4:41 PM

      The relationship of estrogen and brain health is pretty complicated and is being actively researched. Generally,the body’s estrogen does help the brain work better, however supplementing post-menopausal women has not generally been shown to help in research studies. There may be a “critical window” during which estrogen supplementation does help, that is being researched. It might also make a difference when a woman started estrogen supplementation. You can learn more about that here (esp see the section “Human studies and the critical period hypothesis”
      Estradiol and cognitive function: Past, present and future

      In terms of whether you should continue taking hormones, the general principle is that you should ask your health providers to help you estimate the likely risks of doing so, given your particular health history, and then you should try to decide whether the benefit of continuing (presumably the benefit is managing your hot flashes) seems worth the risk. In general hormones can cause some increased risk of cardiovascular disease and of breast cancer. Good luck!

      Reply
  6. Kat Douglass says

    February 24, 2020 at 10:32 PM

    What are your thoughts on “brain boosting” supplements that contain ingredients like Bacopa monnieri, Ginkgo biloba, L-glutamine and Phosphatidylserine (to name a few).

    Research looks inconclusive but also look like they may do some good ?

    Reply
    • Nicole Didyk, MD says

      February 26, 2020 at 5:40 PM

      Hi Kat. All of the compounds you mention have been advertised as being able to protect the brain and prevent Alzheimer’s. Many of them have been studied in animals, and some in humans, but none of them have been shown to actually prevent or treat Alzheimer’s or another type of dementia.

      Here’s what Dr. K had to say about Ginkgo, and we don’t have any more evidence today than we did in 2018. I would focus on exercise, healthy diet, and building a strong social network, rather than recommending any of those supplements.

      Reply
  7. Muguette Goufrani says

    February 6, 2021 at 2:50 PM

    Great articles for aging health

    Reply
  8. Tim says

    September 10, 2021 at 9:45 AM

    Hi, I have had mild to moderate social anxiety since being a teenager. I am now age 58. My doctor had me taper off an SSRI Celexa to Lamotrigine because two years ago I began experiencing fatigue and more anxiety. When I started Lamotrigine I noticed my small motor skills like playing the guitar declined, I developed hand shaking make it difficult to operate a computer mouse and brush my teeth. I have always experienced a weak shaky voice to a small extent but have noticed this past summer my voice trembles more to the degree of someone having essential tremor but I don’t think it’s that. I think it’s related to the mood stabilizer and possibly coming off an SSRI which used and worked for years at stabilizing my anxiety. I have discussed this with my specialist and MD. She is starting by referring me to an ENT who has the means of referring to further specialists like neurologist or speech therapist. My fatigue has been looked after but why more stressed now and have this shakiness. I’m trying to find this out in the hopes of resolving this issue. It’s embarrassing when you have difficulties speaking like this. Any info you have on side effects like I am experiencing would be much appreciated please. Thanks.

    Reply
    • Nicole Didyk, MD says

      September 11, 2021 at 6:18 PM

      Lamotrigine is an anti-epileptic medication and can be used for treatment of anxiety or as a mood stabilizer in someone with bipolar disorder, as you probably know. Tremor is a rare side effect of lamotrigine. Discontinuation of an SSRI like citalopram (Celexa) can cause tremor, among other symptoms that we consider part of a discontinuation syndrome, but that usually doesn’t last more than a few weeks at most.

      Tremor of the hands , voice, or head can be a part of a condition called essential tremor, which can become more prominent later in life. To reduce the symptoms of essential tremor, we recommend the following:
      1. Avoid caffeine and stimulants
      2. Minimize stress
      3. Review other medications that could make tremor worse (such as salbutamol)
      4. If symptoms are severe medication like a beta blocker might help
      I hope you get some answers with your doctors.

      Reply
      • Tim says

        September 15, 2021 at 6:26 PM

        Thank you very much Dr.
        Tim

        Reply
  9. FB says

    October 12, 2021 at 5:08 AM

    Dear Dr.

    i first noticed changes in my mental function such as memory around 30 years. I had noticed first mood changes around my middle to late teenage (parental violence, abuse and neglect) but did not develop depression anxiety and ComplexPTSD (or in my case more aptly referred to by some leading mental health professionals as Developmental Trauma Disorder) the way I experience it now, not until my mid thirties following an abusive marriage.
    In my early 40s now, It has been a difficult journey – trying to diagnose myself (owing to lack of awareness and experience among general practitioners and even specialists) , trying to find effective therapies that work (Five years of SSRIs – the norm here, did nothing to help except for side effects) trying to pursue higher education but the reality has meant that a few relapses resulting from my struggle fighting and navigating a horrible health and social system has set me back as I’ve completely lost the only motivation I had left – academic study. I was interested in your articles because of my own awareness of how great my cognitive abilities were and the sad reality of what is today – not even knowing what my capabilities are anymore if I am to get well, if I am to function and move forward towards a future. My disability means I’ve no means to access effective and successful non pharmaceutical therapies such as neurobiofeedback, somatic experiencing, etc. I have no support network either as I’m someone who has sought refuge in a quite insular Western country. Do you have any realistic advice for me on how I can look after my mental health with motivation if I am to not continue declining? There’s no point to life and living with no ability and poor health.

    Reply
    • Nicole Didyk, MD says

      October 16, 2021 at 11:52 AM

      Thanks for the detailed information about your experience and I wish I could change some of the systemic challenges you’re facing.

      We all have to work with the ,medical resources and system that we have available, and of course there are limitations.

      It sounds to me like you have incredible insight into your situation, and that’s very valuable. It also means that you already have a clear idea of what is and isn’t going to be helpful. I have patients in a similar situation who have derived tremendous help from psychotherapy (talk therapy) with the right therapist. Many of these patients use free counselling services, services affiliated with a faith community, or they are able to budget to afford the help they need.

      It also sounds like a cliche but there’s emerging evidence that physical activity can make a difference in the biochemical profile of a person living with PTSD.

      There’s no “magic bullet” answer to complex brain health concerns, as you probably know. Those who keep reaching out for help are more likely to make progress in the right direction and I’m glad you reached out today.

      Reply

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